On July 6, 1941, Senno was occupied by German troops, but on the same day it was liberated by the counterstrike of the 20th Army under the command of Lieutenant General P.A. Kurochkin. On July 6-10, one of the largest tank battles of the beginning of the war took place near Senno (more than 1500 tanks on both sides) — the Lepel counterstrike. On July 9, the town was again captured by the 17th tank division of the Wehrmacht. From July 10, 1941, to June 25, 1944, the Sennen region was occupied by German-fascist invaders.
In November 1941, in Senno on Michurin Street (former Golynka), the fascists created a Jewish ghetto. All Jews of the town (1056 people, 24.5% of the population according to the 1939 census) were driven into the ghetto and destroyed. On December 31, 1941, the Germans surrounded Golynka Street and drove the residents to be shot at pre-dug pits. On that day, 965 people were shot.